adoptr: Adaptive Optimal Two-Stage Designs

Optimize one or two-arm, two-stage designs for clinical trials with respect to several implemented objective criteria or custom objectives. Optimization under uncertainty and conditional (given stage-one outcome) constraints are supported. See Pilz et al. (2019) <doi:10.1002/sim.8291> and Kunzmann et al. (2021) <doi:10.18637/jss.v098.i09> for details.

Version: 1.1.1
Imports: nloptr, methods, glue
Suggests: knitr, rmarkdown, testthat, covr, rpact, vdiffr, pwr, dplyr, ggplot2, tidyr, gridExtra, bookdown
Published: 2024-10-02
DOI: 10.32614/CRAN.package.adoptr
Author: Kevin Kunzmann ORCID iD [aut, cph], Maximilian Pilz ORCID iD [aut, cre], Jan Meis ORCID iD [aut], Nico Bruder ORCID iD [aut]
Maintainer: Maximilian Pilz <maximilian.pilz at itwm.fraunhofer.de>
BugReports: https://github.com/optad/adoptr/issues
License: MIT + file LICENSE
URL: https://github.com/optad/adoptr, https://optad.github.io/adoptr/
NeedsCompilation: no
Citation: adoptr citation info
Materials: README NEWS
CRAN checks: adoptr results

Documentation:

Reference manual: adoptr.pdf
Vignettes: Get started with adoptr (source, R code)
The adoptr Package: Adaptive Optimal Designs for Clinical Trials in R (source, R code)
Composite Scores (source, R code)
Conditional Scores and Constraints (source, R code)
Defining New Scores (source, R code)
Designs for non-normal Endpoints with approximately normal test statistics (source, R code)
Working with priors (source, R code)

Downloads:

Package source: adoptr_1.1.1.tar.gz
Windows binaries: r-devel: adoptr_1.1.0.zip, r-release: adoptr_1.1.1.zip, r-oldrel: adoptr_1.1.0.zip
macOS binaries: r-release (arm64): adoptr_1.1.1.tgz, r-oldrel (arm64): adoptr_1.1.1.tgz, r-release (x86_64): adoptr_1.1.1.tgz, r-oldrel (x86_64): adoptr_1.1.1.tgz
Old sources: adoptr archive

Reverse dependencies:

Reverse depends: adestr

Linking:

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