SITH: A Spatial Model of Intra-Tumor Heterogeneity

Implements a three-dimensional stochastic model of cancer growth and mutation similar to the one described in Waclaw et al. (2015) <doi:10.1038/nature14971>. Allows for interactive 3D visualizations of the simulated tumor. Provides a comprehensive summary of the spatial distribution of mutants within the tumor. Contains functions which create synthetic sequencing datasets from the generated tumor.

Version: 1.1.0
Depends: R (≥ 3.6.0)
Imports: Rcpp (≥ 1.0.4), scatterplot3d, stats, graphics, grDevices
LinkingTo: Rcpp
Suggests: rgl, igraph, knitr, rmarkdown, testthat
Published: 2021-01-05
DOI: 10.32614/CRAN.package.SITH
Author: Phillip B. Nicol
Maintainer: Phillip B. Nicol <philnicol740 at>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: yes
Materials: NEWS
CRAN checks: SITH results


Reference manual: SITH.pdf
Vignettes: Simulating spatial tumor growth with SITH


Package source: SITH_1.1.0.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): SITH_1.1.0.tgz, r-oldrel (arm64): SITH_1.1.0.tgz, r-release (x86_64): SITH_1.1.0.tgz, r-oldrel (x86_64): SITH_1.1.0.tgz
Old sources: SITH archive


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